Postpartum depression -- This is a far more serious condition than postpartum blues, affecting about one in 10 new mothers. If you've had postpartum depression before, your risk increases 50 to 80%. You may experience alternating "highs" and "lows," frequent crying, irritability and fatigue, as well as feelings of guilt, anxiety and inability to care for your baby or yourself. Symptoms range from mild to severe and may appear within days of the delivery or gradually, even up to a year later. Although symptoms can last from several weeks up to a year, treatment with psychotherapy or antidepressants is very effective.