I can see post-pardum depression as being something Hermione might have to endure. There are also about a thousand unpleasant qualities of pregnancy, and mood swings -- while they are there -- are not the things I've heard most women complain about during pregnancy. I would say the general body changes are enough to really get to most women, but Hermione isn't particularly vain, so she might not care as much about getting bigger. Morning sickness seemed to be the bane of existance for my one teacher when she got pregnant. Here is a list of common pregnancy symptoms:
What do you think she would complain about most during her pregnancies?