I think, growing up with Andromeda, Ginny, and Hermione all as strong female role models in his life, he would be pretty comfortable with girls, yes.
In my stories, the first Weasley grandchildren where all girls with Louis (the first boy) not being born still Teddy is five. Given this, growing up, most of Teddy's playmates were girls.
Do you think when Teddy first arrived at Hogwarts, given this information, do think he would have bonded better with the female students at first. Later, he probably have more guy friend, but early on, do think he would find it easier to make friends with the girls in his class? I'm considering making his two best friends girls.